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KMID : 0356620130280030221
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Journal of Korean Society of Endocrinology
2013 Volume.28 No. 3 p.221 ~ p.225
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Thyroid Dysfunction Associated with Administration of the Long-Acting Gonadotropin-Releasing Hormone Agonist
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Han Eun-Jin
Song Ha-Do
Yang Ji-Hoon
Park So-Young
Kim Sung-Hoon
Yoon Hyun-Koo
Yim Chang-Hoon
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Abstract
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Gonadotropin-releasing hormone (GnRH) agonist has been used in the treatment of a wide variety of sex-hormone-related diseases, as the administration of GnRH agonist can alter the secretion of gonadotropin and sex hormones. Recently, we found that the long-acting GnRH agonist aggravated hyperthyroidism and induced painless thyroiditis. This is the first report to demonstrate the association of thyroid dysfunction with GnRH agonist injection in Korea. Here, we report three cases and emphasize the clinical importance of this aggravating factor in autoimmune thyroid disease.
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KEYWORD
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Gonadotropin-releasing hormone agonist, Graves’ disease, Painless thyroiditis
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